Similarly, alterations in NOTCH1 also co-segregate with BRCA1. Dysregulated activation of NOTCH1 promotes development of prostate cancer metastasis and castration-resistance by altering signaling through multiple oncogenic pathways including AKT, Myc, and Ras/Raf/MAPK pathway (9). The gene discussed is BRCA1; the disease is prostate carcinoma.