To investigate the differential TRAF3IP3 transcriptional and proteomic expression and clarify the potential prognostic value of TRAF3IP3 in patients with glioma, we analyzed gene expression profiles and clinical data from The Cancer Genome Atlas (TCGA) and various public databases, deciphering the underlying biological interaction networks, and the prognostic value of TRAF3IP3 gene expression. Here, TRAF3IP3 is linked to glioma.