Next, we analyzed the DEGs and PPI subnets related to glioma and obtained five key genes: TRAF3IP3, WIPI1, ARHGAP11A, ABCB8, and RHOQ. By analyzing the expression of these genes in normal and tumor tissue, we found that they were significantly differentially expressed in normal and tumor tissue, reflecting a clear predictive value for glioma. This evidence concerns the gene ABCB8 and central nervous system cancer.