CCT3 and breast carcinoma: further explored the mechanism of action of CCT3 in breast cancer was performed through gain-and loss-of-function studies and found that CCT3 can directly bind mir-223 through the ceRNA network between mir-223 and β-catenin, thus affecting the activation of the Wnt/β-catenin signaling pathway, attenuating the regulation of mir-223 in the Wnt/β-catenin pathway and promoting breast cancer cell proliferation and tumorigenicity (45).