STAT3 is an important downstream signaling molecule of numerous growth factors and cytokines, and participates in various biological processes, such as cell proliferation, differentiation, and survival. STAT3 can be activated by nonreceptor tyrosine kinases such as Janus kinases (JAKs) in a tyrosine phosphorylation dependent-manner. CCT3 down regulation could sensitize lung adenocarcinoma cells to cisplatin by inhibiting the Janus kinase 2/signal transducer and activator of the transcription 3 (JAK2/STAT3) pathway. This evidence concerns the gene CCT3 and lung adenocarcinoma.