The objectives of this study were 1) to understand whether CDCA4 expression correlates with clinical and pathological aspects in patients with LUAD; 2) to investigate the predictive value of CDCA4 in LUAD; 3) to evaluate the expression model of CDCA4 in tumour and peritumor lung tissues, and 4) to understand the underlying mechanisms using bioinformatics analysis. The gene discussed is CDCA4; the disease is neoplasm.