Furthermore, GSEA indicated that in the high or low CDCA4 expression group, PD-L1 expression and PD-L1 checkpoint pathway in cancer, Fc gamma R-mediated phagocytosis, intestinal immune network for IgA generation, homologous recombination, proteasome, DNA replication, RNA transport, cell cycle and Spliceosome were enriched (Figures 5A–I). This evidence concerns the gene CD274 and cancer.