Recently, the Consortium to Inform Molecular and Practical Approaches to CNS Tumor Taxonomy working committee considered that histologic grade II and III IDH wild-type astrocytic gliomas should be referred to as diffuse astrocytic glioma, IDH-wild-type, for these gliomas contain high-level EGFR amplification or TERT promoter mutations (27, 29). Here, EGFR is linked to central nervous system cancer.