The treatments for osteoporosis include the following: (1) basic prevention, such as lifestyle adjustment (diet and outdoor sports) and basic bone health supplements (calcium and vitamin D); (2) drug interventions, such as antibone resorption drugs (bisphosphonates, calcitonin, selective estrogen receptor modulators (SERMs), and estrogen); (3) drugs that promote bone formation, such as targeted drugs [2–4]. This evidence concerns the gene ESR1 and osteoporosis.