LOX and Alzheimer disease: After consulting domestic research materials, it was found that a high Hcy level will increase the cerebrovascular endothelial damage and prethrombotic status in patients with AD, and other materials also indicate that a high Hcy level in the body will inhibit the activity of lysyl oxidase itself in the vascular endothelial cells, generating superoxide anions and derivative substances such as nitric oxide nitrite in the body, so that the body will be accompanied by damage to the nitric oxide pathway, and may have an excessive oxidative stress response [15].