This TFEB‐mediated effect has been widely demonstrated in several cellular and mouse models of human diseases which are characterized by an accumulation of undegraded substances(e.g. AD,33, 34, 35 PD,36, 37, 38, 39 HD40, 41) as well as lysosomal storage diseases (LSD),27, 31, 42 among others. The gene discussed is TFEB; the disease is Parkinson disease.