TFEB and juvenile neuronal ceroid lipofuscinosis: Moreover, a recent study revealed that trehalose can activate TFEB by diminishing AKT activity, an upstream kinase that phosphorylats TFEB at Ser467, thereby enhancing the clearance of proteolipid aggregates and reducing neuropathology in a mouse model of Batten disease, a prototypical neurodegenerative disease presenting with intralysosomal storage.69