Trehalose enhances the degradation of polyQ‐AR (which is associated with SBMA), TDP‐43, and SOD1 (which are associated with ALS) via the TFEB pathway in an mTOR‐independent manner, while silencing TFEB disturbs the pro‐degradation activity of trehalose.170, 171. This evidence concerns the gene TARDBP and amyotrophic lateral sclerosis.