This TFEB‐mediated effect has been widely demonstrated in several cellular and mouse models of human diseases which are characterized by an accumulation of undegraded substances(e.g. AD,33, 34, 35 PD,36, 37, 38, 39 HD40, 41) as well as lysosomal storage diseases (LSD),27, 31, 42 among others. This evidence concerns the gene TFEB and Alzheimer disease.