STUB1 and COVID-19: Notably, the frequency of CHIP in our cohort is substantially higher than that reported in the studies led by Jaiswal and Genovese in the general population (10% in people older than 65 years and up to 18% in patients over 90 years, respectively [2, 3]) and also than frequencies reported in COVID-19 patients by Hameister and colleagues (25%) [8], Petzer and colleagues (19.4%) [7], and Bolton and colleagues (20% when the 89 genes overlapping the two cohorts studied were considered) [9].