MET and neoplasm: The mean ratio of the c-MET area (marked by diaminobenzidine, DAB) over the total tumor tissue area was 57.3% ± 17.8%, which was significantly higher than in normal mucosal epithelium (8.4% ± 3.6%) or in the deep muscular margin (4.1% ± 2.2%), indicating high c-MET expression in the tumor (Fig. 2B; p < 0.0001 in both compared groups).