DDIT3 and plasma cell myeloma: The high baseline expression of BIM in ALMC-1 cells is likely driven by ongoing ER stress, which is consistent with the high expression of the ER-stress associated master transcription factors ATF4 and CHOP in these cells as compared to lymphoma or multiple myeloma cells (Figure S1e) and previous reports linking ER stress to BIM upregulation57–59.