The decrease in BAD levels in ALMC-1 cells would allow for increased sequestration of activator BH3-only proteins or the effectors BAX or BAK by BCL-2, BCL-XL, or BCL-W and could result in increased sensitivity to ABT-199, which is what we found in the chemosensitivity results for the AL but not MM cell lines. Here, BCL2 is linked to Miyoshi myopathy.