The high baseline expression of BIM in ALMC-1 cells is likely driven by ongoing ER stress, which is consistent with the high expression of the ER-stress associated master transcription factors ATF4 and CHOP in these cells as compared to lymphoma or multiple myeloma cells (Figure S1e) and previous reports linking ER stress to BIM upregulation57–59. The gene discussed is ATF4; the disease is plasma cell myeloma.