EGFR and neoplasm: The polysaccharide bound to the extracellular domain of epidermal growth factor receptor (EGFR), inhibited its activation and downstream signalling pathways, blocked EMT process, and inhibited expression of Snail, N-cadherin and MMP-2/9, but upregulated E-cadherin.114 In LLC murine artificial pulmonary metastatic model, where subcutaneously implanted tumours were surgically removed and the resulting lung metastasis was caused by blood CTCs, the polysaccharide significantly reduced CTC-induced lung metastasis.