In previous studies, our group as well as others have reported the importance of endothelial IL-1R1 signaling in the neuroinflammatory processes taking place at the blood-brain barrier (BBB) and BSCB in the experimental autoimmune encephalomyelitis (EAE) mouse model of multiple sclerosis20–22,48. Here, IL1R1 is linked to experimental autoimmune encephalomyelitis.