MYC and leukemia: Moreover, it has been detected that eccDNA contains amplified MYC in leukemia.200–202 L Abbate A et al. performed a range of high-resolution genomic methods and revealed a large cohort of acute myeloid leukemia (AML) cases harboring MYC amplification in the form of DM, HSR, and ring chromosomes.203,204 Besides, several studies have also detected MYC-containing eccDNA in GBM, colon cancer, and ovarian cancer.2,147,205