In the second type, MYCN amplicons are characterized by the presence of distal chromosomal fragments harboring CRC-driven enhancers.166 Likewise, the local enhancer hijacking is also involved in EGFR amplification in GBM.239 Morton et al. revealed EGFR amplicon patterns in eccDNA from primary GBM sequencing. Here, EGFR is linked to colorectal carcinoma.