MYC and leukemia: EccDNA is a major source of somatic rearrangements in various types of cancer, resulting in oncogenic remodeling through reintegration into the linear genome.88 Reintegration of eccDNA could cause gene dysregulation, resulting in the defective balance of proto-oncogenes and tumor suppressor genes, which further contributes to tumorigenesis.242 In leukemia, Von Hoff DD et al. used gel electrophoresis techniques to locate the amplified MYC oncogene sequences in leukemia cells.