MYC and malignant colon neoplasm: However, it has been further demonstrated that HU treatment eliminated oncogene-containing DMs but did not decrease the copy number of oncogenes amplified on HSRs, which indicates that oncogene amplification is more stable on HSRs, rather than on ecDNAs.87 Another study showed that HU is able to eliminate DMs with amplified copies of MYC in colon cancer, leading to a reduction in tumorigenicity.249 Overall, drugs that promote S-phase budding may be valuable in the treatment of colon cancer.