They detected a new oncogene called MYCN, whose amplification sequence was located on DMs in the human neuroblastoma cell line IMR-32.39 More recently, a genome-wide landscape of extrachromosomal DNA circularization in neuroblastoma confirmed that the MYCN gene is amplified on eccDNA in neuroblastoma199 (Fig. 7). This evidence concerns the gene MYCN and neuroblastoma.