Recent reports show that super-enhancers are preferentially amplified in ovarian cancer.305 Indeed gene amplification occurs frequently in ovarian cancer.306 In addition, loss of the PGC gene TFAP2C leads to a high rate of germ cell tumors in mice, resembling pediatric Type I germ cell tumors in humans.201 DMRT1, a spermatogonia marker, is highly expressed in germ cell neoplasia in situ, and drives in vivo reprogramming and propagation of GCT-like tumor cells,307 indicating a shared feature of DMRT1-mediated reprogramming in germ cell tumors. Here, TFAP2C is linked to testicular germ cell tumor.