For example, isochromosome 12p is common in seminomas and non-seminomas.280,290–294 KIT-KITLG mutations or their signaling activation,262,264,275,281,295–299 deletions of genes (e.g. SOX17, the gr/gr deletion on chromosome Y),279,300 structural variation, duplication, and loss of chromosomes,301–304 and aneuploidy302 are frequently detected in germ cell tumors. The gene discussed is SOX17; the disease is seminoma.