,68 Organoid-based models have also provided further evidence for EMT in intestinal diseases such as CD.69, 70, 71, 72, 73 Pivotal work from Hahn et al demonstrated the ability of TNF-α and TGF-β to induce EMT in IEOs; mesenchymal phenotypic changes were observed in the TGF-β1-stimulated IEOs. This evidence concerns the gene TGFB1 and intestinal disorder.