Moreover, NSUN2 in HCC tissues was strongly correlated with the high methylation and expression of target genes, including GRB2, RNF115, AATF, ADAM15, RTN3, and HDGF. Li et al. found that NSUN2 coordinates with lin-28B, a novel m5C recognition protein, to catalyze the m5C modification of GRB2 and stabilize its mRNA expression. This evidence concerns the gene HDGF and hepatocellular carcinoma.