For example, METTL3 regulates SOX2 mRNA in glioma stem cell maintenance and colorectal tumor progression (23, 24), LEF1 in osteosarcoma progression (25), AFF4/NF-kB/MYC in bladder cancer (26), and SPHK2 in gastric cancer (27). This evidence concerns the gene SOX2 and osteosarcoma.