We hypothesized that different m6A reader proteins might be involved in the m6A-mediated regulation of JUN and JUNB. To find the candidate m6A reader proteins for JUN and JUNB, we examined the effect of shRNA-mediated knockdown of each m6A reader on the expression of JUN and JUNB proteins in A549 lung cancer cells (Fig. 5A). The gene discussed is JUN; the disease is lung carcinoma.