NFKB1 and cancer: For instance, aberrancy of TNF receptor-associated factor-2 (TRAF2), TRAF3, and baculoviral inhibitor of apoptosis proteins repeat-containing 3 (BIRC3)) can stimulate cancer cell survival by activating the alternative NF-kB pathway via the intermediate signal molecule mitogen-activated protein kinase kinase kinase 14 (MAP3K14) [338].