Ibrutinib can also be combined with targeted therapeutics, such as BCL-2 inhibitor (venetoclax), PI3K inhibitor (umbralisib), and STAT-1 inhibitor (fludarabine), allowing for chemotherapy-free approaches to obtain CR in both previously untreated and R/R CLL patients. The gene discussed is BCL2; the disease is B-cell chronic lymphocytic leukemia.