Then, ADM expression was determined within a normal human glial cell line SVG p12 and glioma cell lines (U87-MG, A-172, LN-229, and T98G) using qRT-PCR; ADM expression was dramatically increased within glioma cell lines than that within SVG p12 cell line, in particular in LN-229 cells (Fig. 1E). Here, ADM is linked to central nervous system cancer.