GHRHR and isolated congenital growth hormone deficiency: We have described a large cohort of individuals residing in Itabaianinha, in the Brazilian state of Sergipe, with severe short stature, but near normal ocular axial length [16], due to a congenital isolated GHD (IGHD), caused by the c.57 + 1G > A mutation in the GH releasing hormone receptor (GHRHR) gene (GHRHR OMIM n.618157) [17].