Using the discovery cohort of patients with residual tumor following neoadjuvant treatment (TRG 2-5, n = 39; 1 patient sample unable to be assessed), we stained for CD15+ cells as a surrogate marker for tumor-infiltrating neutrophils (Fig. 3A).15 Although high CD15+ cell infiltration was not associated with nodal status at the time of resection (Fig. 3B), we did observe a significant association of higher CD15+ cell infiltration in the resected specimen from patients with recurrent disease at 2-year follow-up (Fig. 3C). The gene discussed is FUT4; the disease is neoplasm.