Several cytokines involved in COVID-19 including IL-6 mainly act by Janus kinase-Signal transducer and activator of transcription (JAK-STAT) signaling, one important pathway with a pivotal role in various biological processes including hematopoiesis, immune development, inflammation control, adipogenesis, etc. As major downstream effectors of cytokine signaling, JAKs can be therapeutic targets of cytokine-dependent inflammatory and neoplastic disorders. This evidence concerns the gene IL6 and COVID-19.