Logistic regression analysis of age, BMI, FPG, HbA1c, FINS, HOMA-IR, TG, TC, LDL-C, HDL-C, LH, FSH, T, SHBG, PRL, and E2 was performed to analyze the independent correlation between miR-222-3p and cardiovascular complication in PCOS patients. The gene discussed is SHBG; the disease is polycystic ovary syndrome.