Average cumulative incidences of CRC (with 95% confidence intervals in parentheses) in path_MLH1, path_MSH2, path_MSH6 and path_PMS2 carriers at 70 years of age were 52 (45-59)%/ 41 (35-48)%, 50 (42-58)%/ 39 (33-46)%, 13 (7-25)%/ 17 (11-26)% and 11 (3-37)%/ 8 (2-29)% in male/female carriers in the total cohort, respectively. The gene discussed is PMS2; the disease is colorectal carcinoma.