Since recent investigations have already explored the specific mechanism of YAP1 related to NCOA4-mediated ferritinophagy or FTH1 degradation, we hypothesized that YAP1 inhibited NCOA4-mediated ferritinophagy, producing a decrease in free ferrous iron, and protected hepatocyte from ferroptosis in sepsis mice. The gene discussed is FTH1; the disease is Sepsis.