Two patients diagnosed with relapsed Ewing sarcoma and suggested cell cycle activation due to high expression of CCND1 (expression log2 Z-score 2.2 and 2.0, respectively; low priority) remained on a regimen of ribociclib combined with topotecan and temozolomide for 181 and 176 days, respectively, as reported by others [30]. This evidence concerns the gene CCND1 and Ewing sarcoma.