SOD1 and amyotrophic lateral sclerosis: In a SOD1 mouse model of ALS, intravenous human umbilical cord blood (hUCB) mononuclear cell treatment increases the life span of the mice.141,142 This life span improvement is dependent on stem cell dosage, as a dose of 70.2-73.3 × 106 cells shows a greater positive impact than 33.2-33.4 × 106 cell dosage.