GNAI1 and amyotrophic lateral sclerosis: This miRNA is notable for promoting neuronal growth and vascular strength in the brain and may be another potential target for amplifying stem cell effects in ALS.168 Another target miRNA is miR-125b, which, when inhibited, amplifies anti-inflammatory microglial proliferation and NTFs such as BDNF.169,170 Neurotrophic bone marrow cellular nests are also shown to reduce MN degeneration and death and stabilize functional residual capacities and ALSFRS scores.171 Another stem cell adjustment may involve Gi signaling pathways.