MCP-1 is increased in ALS CSF samples and high glial cell MCP-1 concentrations are positively correlated with accelerated disease progression.22,157,158 Unfortunately, most trials can only report safe administration with weak symptom relief.154,159-163 This has not perturbed researchers, however, and various methods and stem cell variations continue to be tested to optimize cell-based treatments for ALS. This evidence concerns the gene CCL2 and amyotrophic lateral sclerosis.