Whereas IHC positivity of OTX2 protein is visible in almost all WNT- and non-WNT/non-SHH-MB, these mostly focal gains can only be found in a subset of WNT-activated tumors and similarly in non-WNT/non-SHH-MBs, but not in SHH-MBs. Here, OTX2 is linked to Mobius syndrome.