Moreover, a connection between ERBB signaling and ABCB1 expression has been described in ovarian and lung cancer models: Afatinib decreased ABCB1 expression in ABCB1‐overexpressing cells by inhibiting the activation of PI3K/AKT signaling and NF‐κB activation [46, 54]. The gene discussed is AKT1; the disease is lung carcinoma.