AFP and hepatocellular carcinoma: These results demonstrated that the AFP390–609 fragment also synergized with sorafenib to promote apoptosis in Bel7402 cells (Figure 8A,B), and the effect of AFP390–609 on hepatoma cell apoptosis was similar to that of siRNA‐AFP, also suggesting that the AFP390–609 fragment may promote apoptosis by inhibiting AFP signalling.