ERCC1 and neoplasm: Although the exact mechanism has not been completely clarified, and a larger sample size is also necessary to confirm the findings of clinical investigation, our study integrated the survival analysis of NSCLC patients with in vitro functional exploration and partly explained that rs3212986 polymorphism might be linked with the sensitivity to platinum analogues via affecting the post‐transcriptional regulation of ERCC1 and alter the DNA repair capacity of tumour cells.