CircAP2A2 has been reported to promote IH proliferation and invasion by regulating the miR-382-5p/VEGFA axis.[17] In addition, the study identified 249 differentially expressed candidate genes in the IH group.[18] Therefore, circRNAs play an important role in the proliferation and invasion of infantile hemangiomas (IH). The gene discussed is VEGFA; the disease is isolated hemihyperplasia.