In addition, the top 10 hub genes in the PPI network, including FBXW7, CBLB, HECW2, FBXO32, FBXL7, KLHL5, EP300, MAPK1, MEF2C, and PLCG1, are closely correlated with IH. The gene discussed is KLHL5; the disease is isolated hemihyperplasia.