HFE and central nervous system cancer: A sample was considered G-CIMP-positive when 7 loci (ANKRD43, HFE, MAL, LGALS3, FAS-1, FAS-2, and RHO-F) were hypermethylated and 1 locus, DOCK5, was hypomethylated.[18] Moreover, they also demonstrated that the G-CIMP status was more common in the grade II and III glioma with improved survival.[18] Until recently, classifications based on CIMP-positive versus CIMP-negative, as well as classifications based on IDH1-mutant (G-CIMP-high, G-CIMP-low subgroups), were widely used in a variety of studies for glioma.[35,44] Further studies are needed to verify a consistent CIMP definition.