SMAD2 and cancer: Overexpression of HAND2-AS1 led to the significantly inhibited expression of TGF-β1 and reduced level of p-Smad2/3 in cancer cells.[31] Chen et al[18] showed that knockdown HAND2-AS1 could promote osteosarcoma cell proliferation and glucose uptake by upregulating GLUT1, which is a key protein of glucose metabolism.