The results indicated that low expression of HAND2-AS1 was strongly correlated with the poor OS in both subgroups (digestive system tumors: HR = 0.48, 95% CI: 0.31–0.73, P < .001; non-digestive system tumors: HR = 0.48, 95% CI: 0.32–0.70, P < .001). Here, HAND2 is linked to digestive system neoplasm.