PDCD4 and breast carcinoma: In colorectal cancer, HAND2-AS1 could suppress cell progression and 5-FU resistance by upregulating PDCD4 via sponging miR-20a.[16] Dong et al[30] uncovered that HAND2-AS1 could suppress breast cancer cell growth by regulating the miR-3118/PHLPP2 signaling axis.