For example, ADH1A triggered oncogenic transformation of hepatocytes leading to poor survival,[21] whereas extracellular PEDF inhibited angiogenesis in HCC by inducing lipid metabolic disorders.[22] These insights into the molecular mechanisms and genes markers involved in the pathogenesis of HCC have extended our understanding of the metabolic profile of HCC. The gene discussed is SERPINF1; the disease is Disorder of lipid metabolism.