We found that HCC patients with high-risk scores had higher mortality rates than those with low risk scores, and the changes in expression of 6 LMRGs with increased risk score revealed that SLC11A1, RNF10, KCNH2, ME1, and ZIC2 as hazard index and FMO3 as protective index (Fig. 3A). Here, ZIC2 is linked to hepatocellular carcinoma.