Consistent with a previous study, we found that FMO3 suppresses tumor progression by decreasing cell viability, hence it is a protective index.[23] In addition, our analysis revealed that ME1 or ZIC2, which exhibit stem-cell features, correlated with poor prognosis, hence are risk indexes.[24,25] However, these previous studies reported the presence of potential errors and bias in their analyses. Here, ZIC2 is linked to neoplasm.