We found that HCC patients with high-risk scores had higher mortality rates than those with low risk scores, and the changes in expression of 6 LMRGs with increased risk score revealed that SLC11A1, RNF10, KCNH2, ME1, and ZIC2 as hazard index and FMO3 as protective index (Fig. 3A). This evidence concerns the gene FMO3 and hepatocellular carcinoma.