Osteoclasts are multinuclear bone-resorbing cells differentiated from monocyte/macrophage lineage cells and depending on the receptor activator of nuclear factor κB (RANKL).[13] Osteoclasts differentiation plays a key role in a steady-state RA and is controlled by Group 2 innate lymphoid cells in the bone marrow (BM ILC2s). Here, TNFSF11 is linked to rheumatoid arthritis.