TG and Sezary syndrome: When thyroid hormone levels are low, glycolysis and oxidative phosphorylation can be downregulated, followed by a decrease in adenosine triphosphate, as well as CK accumulation and leakage from cells; moreover, a decrease in CK clearance is also an important reason for CK elevation.[15] In our study, CK was negatively correlated with FT3 and FT4, which supports the view that abnormal muscle enzymes in patients with Sheehan’s syndrome are associated with hypothyroidism.