These substances can stimulate renal vasoconstriction, are deposited and block the distal renal tubules and directly exert cytotoxicity via endocytosis in the proximal renal tubules.[40] Acute kidney injury in Sheehan’s syndrome is not very common, with few cases having been reported in the literature, most of which were caused by RM.[20,41–43] In our study, 4 (29%) out of the 14 patients in Group 1 (CK ≥ 1000 U/L) showed only mild renal dysfunction with increased myoglobin. This evidence concerns the gene MB and Sezary syndrome.