Some studies found that HRT had no significant impact on the lipid profile, and some women still developed dyslipidemia despite HRT.[4] Other findings from large randomized trials also do not confirm the benefit of estrogen therapy for the prevention of cardiovascular disease, and HRT is not recommended for this purpose in clinical practice.[7] Clinically, we also found that by using HRT, although FSH decreased, no effect on the lipid profile was found. This evidence concerns the gene BRD2 and metabolic syndrome.