Therefore, all candidate predictors with statistical significance (P < .05) in the univariate analysis were included as independent variables into the multivariate logistic regression model: the independent variables included in the regression analysis with LVI as the dependent variable were tumor grade, tumor stage, T stage, N stage; the independent variables included in the regression analysis with PNI as the dependent variable were tumor grade, tumor stage, T stage, N stage, and p53. Here, TP53 is linked to neoplasm.