Tumor grade (P < .001), tumor stage (P < .001), T stage (P < .001), N stage (P < .001) is statistically different between colorectal cancer with and without LVI, which is not statistically significant with gender (P = .276), age (P = .616), mucinous adenocarcinoma (P = .755), tumor size (P = .393), p53 (P = .158), and EGFR (P = .786). This evidence concerns the gene TP53 and colorectal cancer.