INS and MODY: Currently, the commonly used diagnostic criteria for MODY are: at least 1 to 2 patients in the family have a disease onset before the age of 25; at least 3 consecutive generations of autosomal dominant inheritance; generally no insulin treatment required within 5 years after diagnosis; β-cell dysfunction.[9,10] The clinical manifestations of MODY are complex while there is also clinical heterogeneity.