These mutations in the KCNJ11 gene shift the probability of the KATP channels to be active and contain an open configuration causing a plasma membrane hyperpolarization and thereby inhibiting insulin secretion.[15–17] These gene mutations in KCNJ11 can cause neonatal diabetes mellitus, impaired fasting glucose, impaired glucose tolerance, congenital hyperinsulinism, or MODY13.[18–20]. The gene discussed is INS; the disease is neonatal diabetes mellitus.