In addition, SNHG16, SNORD76, and SnoU2_19 regulate HCC progression through the Wnt/β-catenin signaling pathway.[9] Recently, Ding et al indicated that SNORD31, SNORA71A, and RNU5E-1 could be used as prognostic genes for HCC.[10–12] However, research on snoRNA as a prognostic diagnostic marker for HCC is not comprehensive. Here, RNU5E-1 is linked to hepatocellular carcinoma.