SNORD63 was greatly upregulated in urinary sediment and SNORD96A elevated in plasma acted as a noninvasive diagnostic biomarker for clear cell renal cell carcinoma.[28] In our study, we aimed to construct a signature based on snoRNA expression profiles for the classification of patients with HCC, which could be more effective in distinguishing between normal and tumor patients. The gene discussed is SNORD63; the disease is neoplasm.