SNORD63 was greatly upregulated in urinary sediment and SNORD96A elevated in plasma acted as a noninvasive diagnostic biomarker for clear cell renal cell carcinoma.[28] In our study, we aimed to construct a signature based on snoRNA expression profiles for the classification of patients with HCC, which could be more effective in distinguishing between normal and tumor patients. This evidence concerns the gene SNORD63 and neoplasm.