The results showed that SNORA16B and SNORD63 were downregulated in the high-risk group, indicating that they act as protective factors, and SNORA59B, SNORA11, SNORD46, and SNORD124 were upregulated in the high-risk group, indicating that they were all risk factors for HCC. The gene discussed is SNORD63; the disease is hepatocellular carcinoma.