We identified 6 snoRNAs that were significantly related to the prognosis of HCC by data mining and data analysis and constructed a prognostic signature based on 6 prognostic snoRNA expression values (SNORA59B, SNORD46, SNORD124, SNORA11, SNORD63, and SNORA16B). The gene discussed is SNORA16B; the disease is hepatocellular carcinoma.