Indeed, most of these 12 MRGs, including PLAUR [21], RBP1 [22], MRPL36, AGK [23], HK1 [23], APEX1 [24], NUDT1 [25], and PHB2 [26], have been reported to play critical roles in the development and invasiveness of GBM. The gene discussed is APEX1; the disease is glioblastoma.