PMP22 and nerve compression syndrome: HNPP is due to decreased dosage of the PMP22 gene via haploinsufficiency and is inherited as a liability to pressure palsies originally described in the Dutch population and pathologically presenting as tomaculous neuropathy [51, 52]; it is often only manifested clinically as multifocal neuropathy elicited after sustained trauma to a peripheral nerve that traverses close to the body surface and manifest as an entrapment neuropathy [53] or an operative carpal tunnel syndrome co-segregating through multiple generations [27].