AKT1 and hepatocellular carcinoma: Of note, overexpression of specific Akt isoforms has been found in different cancers, such as Akt1 amplification has been reported in breast, gastric cancers, Akt2 in hepatocellular carcinomas, colorectal, ovarian and pancreatic cancers, and Akt3 amplification in estrogen receptor-negative breast tumors and melanoma [6].