In COAD samples with mutations of MAP2 module gene, the infiltration of M1 macrophages (P = 0.05, one-sided Wilcoxon rank-sum test; Additional file 1: Fig. S9B) and Resting Mast Cells (P = 0.02, one-sided Wilcoxon rank-sum test; Additional file 1: Fig. S9C) was lower in the COAD patients with MAP2 low expression than those with MAP2 high expression. This evidence concerns the gene MAP2 and colon adenocarcinoma.