Four CRs (TRRAP, EP300, NSD2 and MSH6) having synthetic lethal interactions with MAP2 were integrated as a MAP2 CSL module in COAD, where MAP2 was affected by two taxnes (Paclitaxel and Docetaxel) (Fig. 7A).These four CRs play roles in cell cycle, notch signaling pathway and mismatch repair in human cancers. The gene discussed is EP300; the disease is cancer.