HLA-C and Alzheimer disease: Other potential limitations in interpretation of our finding is the unknown specificity of human Tregs on modifying neuroinflammation rather than nonspecific effect of human cells in a preclinical AD mice model and also unknown extend of cross-reactivity between human Tregs immunomodulatory markers and mice immune system, as the presence of mice MHC rather than human MHC might limit the function of human Treg.