Some of the hub genes in this gene set were IFITM1, IFIH1, and IFIT family members such as IFIT5, IFIT3, and IFIT1. Additionally, the primary immunodeficiency gene set was enriched in patients without aGVHD when compared with patients who developed aGVHD (NES = 2.05, FDR q-value = 0.015) and healthy controls (NES = 1.59, FDR q-value = 0.098; Fig. 6D). Here, IFIT1 is linked to inborn error of immunity.