As FGF21 was identified as a hepatic endocrine factor which modulates lipid metabolism, and the serum FGF21 level progressively increased with visceral fat, and associated with NAFLD [59], it is reasonable to proposed there is a possible link between FGF21 and prolonged QTc interval via the lipid metabolism happened at epicardial fatty tissue. This evidence concerns the gene FGF21 and metabolic dysfunction-associated steatotic liver disease.