Chou et al. suggested that FGF21 involved in the diastolic heart failure pathophysiology [20] and Shen et al. also reported that among the CAD patients with higher serum level of FGF21, there is a higher incidence of nonfatal myocardial infarction, hospitalization, cardiac death and major adverse cardiovascular events (MACEs) [21, 22]. Here, FGF21 is linked to myocardial infarction.