New association signals from cross-ancestry GWASs included, for example, variants at PROCR, GRK5 and F11 (thrombosis), LPA and ATP2B1 (lipid metabolism, hypertension and atherosclerosis), SWAP70 (membrane ruffling) and LAMC1 (cerebrovascular matrisome). The gene discussed is GRK5; the disease is hypertensive disorder.